Jimmy Garoppolo threw four touchdown passes, as the San Francisco 49ers won their third straight game by beating the Arizona Cardinals 38-10 in Mexico City.
Tom Brady stayed undefeated abroad by throwing two touchdown passes to help the Tampa Bay Buccaneers beat the Seattle Seahawks 21-16 in the first regular-season game played in Germany.
Josh Allen threw four touchdown passes, including three to Stefon Diggs, and the Buffalo Bills rolled past Derrick Henry and the Tennessee Titans 41-7 in their home opener.
Brandon McManus missed a 64-yard field goal attempt with 20 seconds left and the Seahawks escaped with another wild victory involving Wilson at quarterback.